|
KMID : 0877220090130010003
|
|
Journal of Korean Epilepsy Society
2009 Volume.13 No. 1 p.3 ~ p.7
|
|
|
Efficacy and Safety of Levetiracetam in Children Younger than 4 Years with Intractable Epilepsy
|
|
Lim Byung-Chan
Cho An-Na
Chae Jong-Hee
Hwang Yong-Seung
Kim Ki-Joong
|
|
|
Abstract
|
|
|
Purpose:The aim of this study was to evaluate the efficacy and safety of levetiracetam in children younger than 4 years with intractable epilepsy.
Methods: A retrospective analysis of pediatric epilepsy patients was performed. Data were obtained from the medical records of 30 patients (male 19, female 11) with intractable epilepsy, who were treated with levetiracetam.
Results: Seizure types were partial in 18, and generalized in 12. Fifteen patients had symptomatic etiologies. The median age of the patients at the time of levetiracetam administration was 26 months old (range: 4-47 months). The median starting dose was 13 mg/kg/ day, and the median maintenance dose was 52 mg/kg/day (range: 10-123 mg/kg/day). Ten (10/30, 33%) patients experienced more than 50% reduction in seizure frequency, and 4 (4/30, 13%) partial epilepsy patients became seizure-free. Eight partial epilepsy patients (44%) had more than 50% seizure reduction, while 2 patients (17%) with generalized epilepsy did. All of patients with infantile spasms and Lennox-Gastaut syndrome except one, had less than 50% reduction in seizure frequency. Adverse events reported in 8 patients (27%), included lethargy, behavioral problems, sleep disturbance, and seizure aggravation.
Conclusions: Levetiracetam is effective in children aged 4 years or less with intractable epilepsy, and also seems to be safe to use in this age group.
|
|
|
KEYWORD
|
|
|
Levetiracetam, Anticonvulsants, Intractable epilepsy, Infant, Preschool child
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|